Viagra vs. Cialis: Comparing the differences, side effects and more

Viagra vs. Cialis: Comparing the differences, side effects and more

Viagra (sildenafil) and Cialis (tadalafil) are leading phosphodiesterase-5 (PDE5) inhibitors prescribed for erectile dysfunction (ED). Both enhance blood flow to the penis during sexual stimulation but differ significantly in duration, dosing flexibility, and lifestyle compatibility. Approved in 1998 and 2003, respectively, these medications have become cornerstone treatments for ED, with Cialis also FDA approved for benign prostatic hyperplasia (BPH). SaveHealth, a prescription discount website, explores Viagra vs Cialis.

Viagra vs Cialis - Mechanism of Action

Both drugs work by inhibiting PDE5, increasing cyclic guanosine monophosphate (cGMP) to relax penile smooth muscles and improve blood flow. Key similarities of both include:

• Sexual arousal is required for effectiveness.
• Contraindicated with nitrates due to blood pressure risks.
• Enhance natural erectile response without affecting libido.

Key Differences at a Glance

Viagra vs Cialis - Effectiveness and Duration

• Clinical Success Rates: Both demonstrate 67%-89% effectiveness in clinical trials.
• Duration Advantages: Cialis' 36-hour window earned it the nickname "weekend pill." Viagra's shorter duration may benefit those preferring precise timing.
• Real-World Preferences: 60% of men prefer Cialis for spontaneity, while Viagra users appreciate its predictable four-hour window.

Cialis vs Viagra - Side Effect Comparison

Common to Both:

• Headaches (16%-42% incidence)
• Flushing (2%-19%)
• Nasal congestion (4%-9%)
• Indigestion (2%)

Unique Profiles:

Note: Both carry rare but serious risks of priapism (prolonged erection more than 4 hours).

Dosage and Administration

Viagra Protocol:

• Take one hour before sex on empty stomach.
• Start with 50 mg, adjust to 25-100 mg.
• Max one dose per day.

Cialis Options:

• As Needed: 10-20 mg 30 mins before activity.
• Daily Use: 2.5-5 mg for continuous readiness.
• BPH Treatment: 5 mg daily with consistent timing.

Critical Considerations:

• Hepatic/renal impairment requires dose adjustments.
• Avoid concurrent alpha-blockers without medical supervision (may lead to extreme dizziness, lightheadedness, fainting).

Special Considerations

Lifestyle Factors

Cialis preferred for:

• Spontaneous sexual activity.
• Patients who dine before intimacy.

Viagra ideal for:

• Predictable scheduling.
• Those avoiding daily medication.

BPH Management

Cialis uniquely treats both ED and urinary symptoms through:

• Smooth muscle relaxation in the prostate/bladder.
• Improved urinary flow rates (39% increase in clinical trials).

Cialis vs Viagra - Drug Interactions and Contraindications

Absolute Contraindications:

• Concomitant nitrate use (angina medications)
• Severe hepatic/renal impairment

Key Interactions:

Choosing the Right Medication - Cialis vs Viagra

Consider Cialis If:

• Spontaneity is important.
• You have concurrent BPH.
• Tolerating frequent dosing is challenging.

Consider Viagra If:

• Predictable timing works for your routine.
• You prefer shorter-acting medication.
• Cost is a primary concern (generic sildenafil averages $2 per dose).

Clinical Tip: 40% of nonresponders to one PDE5 inhibitor benefit from switching to the other.

This story was produced by SaveHealth and reviewed and distributed by Stacker.